Sunday, 27 September 2015
Sunday Melanoma Session at ECC2015- Nivo then Ipi versus Ipi then Nivo in Stage 4 Melanoma
Update on CHECKMATE 064- Hodi
Phase 2 , Nivo post Ipi vs Ipi post Nivo in Melanoma
Ipi 3 mg
Nivo 3 mg
1 prior therapy allowed but no Immuno.
Disease progression more in Ipi first
More side effects on Nivo first
Immune- related side effects
Similar to direct combo
50 vs 31% Hepatitis Nivo/ Ipi vs Ipi/ Nivo
ORR 41 vs 20 % confirmed ORR
TUMOUR BURDEN REDUCES FASTER on Nivo first
So- conclusion : Nivo then Ipi higher response rate than Ipi then Nivo but more side effects, similar to what one sees when Ipi and Nivo are giving at the same time.
Caroline Robert commented- surprising as currently one thought that Ipi recruits T-cells that are then activated by PD1.
Also good as it could allow to start with PD1 and only add Ipi when needed, avoiding to limit side effects
Ipi plus Nivo better Nivo/Ipi better than Ipi/ Nivo
To be tested
Intra-tumoral injection of Ipi plus Pd1